Research And Development...
Scientific Articles & Links
"Evolution of Minerals" by Robert M. Hazen (Scientific American March 2010) - Looking at the mineral kingdom through the lens of deep time leads to a startling conclusion: most mineral species owe their existence to life
Mechanisms of Low Level Light Therapy (click here to read article) is by Michael R Hamblin and Tatiana N Demidova of Wellman Center for Photomedicine at Massachusetts General Hospital, Department of Dermatology at Harvard Medical School, Harvard-MIT Division of Health Sciences and Technology, Graduate Program in Cell Molecular and Developmental Biology at Sackler School of Graduate Biomedical Sciences and Tufts University School of Medicine.
Treatment of Helicobacter pylori infection with intra-gastric violet light phototherapy: a pilot clinical trial (click here to read article), an article by Dr. Michael Hamblin, has been selected for inclusion by the Faculty of 1000 Medicine, a literature awareness service that identifies and evaluates the most important articles published in Medicine based on the recommendations of a Faculty of over 2000 peer-nominated leading researchers and clinicians. Lembo AJ, Ganz RA, Sheth S, Cave D, Kelly C, Levin P, Kazlas PT, Baldwin PC 3rd, Lindmark WR, McGrath JR, Hamblin MR.
BACKGROUND AND OBJECTIVE: Helicobacter pylori infects the mucus layer of the human stomach and causes peptic ulcers and adenocarcinoma. We have previously shown that H. pylori accumulates photoactive porphyrins making the organism susceptible to inactivation by light, and that small spot endoscopic illumination with violet light reduced bacterial load in human stomachs. This study assessed the feasibility and safety of whole-stomach intra-gastric violet phototherapy for the treatment of H. pylori infection.
STUDY DESIGN/MATERIALS AND METHODS: A controlled, prospective pilot trial was conducted using a novel light source consisting of laser diodes and diffusing fibers to deliver 408-nm illumination at escalating total fluences to the whole stomach. Eighteen adults (10 female) with H. pylori infection were treated at three U.S. academic endoscopy centers. Quantitative bacterial counts were obtained from biopsies taken from the antrum, body, and fundus, and serial urea breath tests. RESULTS: The largest reduction in bacterial load was in the antrum (>97%), followed by body (>95%) and fundus (>86%). There was a correlation between log reduction and initial bacterial load in the antrum. There was no dose-response seen with increasing illumination times. The urea breath test results indicated that the bacteria repopulated in days following illumination.
CONCLUSION: Intra-gastric violet light phototherapy is feasible and safe and may represent a novel approach to eradication of H. pylori, particularly in patients who have failed standard antibiotic treatment. This was a pilot study involving a small number of patients. Further research is needed to determine if phototherapy can be effective for eradicating H. pylori.
Tosteson Postdoctoral Fellowship Award. We are extremely delighted to share with you that Clemens Alt and Pilhan Kim are recipients of the 2009 Tosteson Postdoctoral Fellowship Award funded by the Massachusetts Biomedical Research Corporation (MBRC).
Clemens' project title is: "Probing microglia microenvironment with adaptive-optics imaging and selective optical microsurgery (click here to read article)" and Pilhan's title is "In vivo longitudinal imaging of colon tumorigenesis in conditional Apc knock-out mice (click here to read article)" Please refer to their project summaries for additional information. This was a very competitive review, Clemens and Pilhan’s proposals were chosen from among 95 applications considered by the MGH Executive Committee on Research (ECOR) and the Subcommittee on Review of Research Proposals (SRRP). Only 10 proposals were awarded. Their one year fellowship will begin September 1, 2009.
NIH Bench to Bedside Pioneer Award. We are very pleased to inform you that Tayyaba Hasan, PhD will receive the highly prestigious NIH Bench to Bedside Pioneer Award. The award ceremony will be held at the NIH Workshop in Bethesda, MD on Thursday, October 1st.
Here is an excerpt from the NIH Workshop website:
"The NIH Bench to Bedside Pioneer Award recipient is Prof. Tayyaba Hasan of the Wellman Center for Photomedicine, Massachusetts General Hospital (MGH), and Harvard Medical School. Dr. Hasan's extraordinary contributions to Biomedical Optics include pioneering activities in basic research, clinical translation, and mentoring young scientists. Her career has spanned a range of topics in Photomedicine including basic photochemistry, photobiology, and photodynamic therapy (PDT), leading to the invention of PDT for treating patients with age-related macular degeneration. Her work in immunotargeting, optical spectroscopy, and in vivo optical imaging of tissue is ongoing through funding from the National Institutes of Health. Dr. Hasan's second appointment in the MGH Office for Research Career Development has her involved in mentoring scientists at all stages of their careers and helping establish pathways for career growth at one of the largest biomedical research institutions in the world."
Plant Biology More Light, Less Disease (click here to read article) by Nancy R. Gough. Science Signaling, AAAS, Washington, DC 20005, USA.
Nasa Study on Light Therapy (click here to read article) Marshall Space Flight Center Dec. 21, 2000 ‘We bring people to space — We bring space to people’. NASA space technology shines new light on healing by Tracy McMahan
Effect of visible light on some cellular and immune parameters. Immunology and Cell Biology, 1995, 73; 239-244. T.Kubasova, M.Horvath, K. Kocsis and M.Fenyö:
M.Fenyö, J.Mandl and A.Falus: Opposite effect of linearly polarized light on biosynthesis of interleukin-6 in a human B lymphoid cell line and peripheral human monocytes. Cell Biology International, 2002, 26(3); 265-269.
Investigations on biological effect of polarized light. Photochemistry and Photobiology T.Kubasova, M.Fenyö, Z.Somosy, L.Gazso and I.Kertesz:, 1988, 48; 505-509. The effect of polarized light on the release of growth factors from the U-937 macrophage-like cell line P.Bolton, M.Dyson and S.Young:. Laser Therapy, 1992, 2(3); 33-37.
Hypothetical physical model for laser biostimulation I.Kertesz, M.Fenyö, E.Mester and G.Bathory:. Optics and Laser Technology, 1982, 16; 31-32.
Single skin exposure to visible light induces rapid modification of entire circulation blood K.A.Samoilova, K.D.Obolenskaya, A.V.Vologdina, S.A.Snopov and E.V.Shevchenko: - 1.
Improvement of rheologic and immune parameters. Progress in Biomedical Optics/Proceedings of Low-Power Light on Biological Systems, 1998, IV; 90-103.
Visible light induces changes in the immune response through an eye-brain mechanism (photoneuroimmunology)J.E.Roberts:, Journal of Photochemistry and Photobiology, B: Biology, 1995, 29(1); 3-15.
The use of polarised polychromatic non-coherent light alone as a therapy for venous leg ulceration.L.Medenica and M.Lens: The Journal of Wound Care, 2003, 12(1); 37-40.
A conservative approach for deep dermal burn wounds using polarised-light therapy S.Monstrey, H.Hoeksema, H.Saelens, K.Depuydt, M.Hamdi, K.Van Landuyt and P.Blondeel:. British Journal of Plastic Surgery, 2002, 55; 420-426.
Effect of polarized light in the healing process of pressure ulcers.P.Iordanou, G.Baltopoulos, M.Giannakopoulou, P.Bellou and E.Ktenas: International Journal of Nursing Practice, 2002, 8(1); 49-55.
The effect of polarized light on wound healing S.Monstrey, H.Hoeksema, K.Depuydt, G.Van Maele, K.Van Landuyt and P.Blondeel:. European Journal of Plastic Surgery, 2002, 24(8); 377-382.
The effect of polarized light on wound healing Invited commentary: W.Vanscheidt,. European Journal of Plastic Surgery, 2002, 24(8); 383.
LE JOURNAL DE MICHEL DOGNA - N°58 FÉVRIER 2008
LE JOURNAL DE MICHEL DOGNA - N°67 JANVIER 2009